UNC93B1 promotes pancreatic cancer progression through modulation of cGAS-STING signaling - PubMed
a day ago
- #Pancreatic Cancer
- #cGAS-STING Pathway
- #Immunosuppression
- UNC93B1 promotes pancreatic cancer progression by modulating the cGAS-STING signaling pathway.
- The study used a multi-omics approach, including single-cell transcriptomics, genomics, and proteomics, to analyze PDAC.
- UNC93B1 was identified as a key gene associated with tumorigenesis and poor prognosis in PDAC.
- Functional validation showed that UNC93B1 knockdown reduced cancer cell proliferation, migration, and clonogenicity.
- UNC93B1 suppresses the cGAS-STING pathway, contributing to an immunosuppressive tumor microenvironment.
- In vivo experiments confirmed that UNC93B1 silencing impeded tumor growth and activated the STING pathway.
- UNC93B1 is a potential diagnostic biomarker and therapeutic target for pancreatic cancer.