Renal outcomes in ANCA-associated vasculitis without clinically apparent kidney involvement: a multicentre REVEAL cohort study - PubMed
2 days ago
- #ANCA-associated vasculitis
- #Chronic kidney disease
- #Systemic inflammation
- Study focuses on renal outcomes in ANCA-associated vasculitis (AAV) patients without clinically apparent kidney involvement.
- Primary outcome was incident chronic kidney disease (CKD) in patients with kidney BVAS = 0.
- eGFR trajectories showed improvement in kidney BVAS ≥1 group post-remission but declined in kidney BVAS = 0 group.
- 30 patients in the kidney BVAS = 0 group developed CKD over three years (cumulative incidence 30.7%).
- Older age and higher baseline-to-1-month time-weighted average C-reactive protein (TWA-CRP) were associated with incident CKD.
- TWA-CRP was identified as a predictor of incident CKD, indicating sustained systemic inflammation's role.
- The study underscores the importance of eGFR monitoring in AAV patients even without apparent kidney involvement.