Clonal hematopoiesis mutation is associated with risk of incident lung cancer and death - PubMed
3 hours ago
- #Clonal hematopoiesis
- #Lung cancer
- #Mortality
- Clonal hematopoiesis (CH) mutations are linked to increased risk of lung cancer and higher mortality rates.
- Study based on UK Biobank data with 3,750 lung cancer cases and 18,687 controls showed CH mutations more frequent in cases (11.39%) vs. controls (8.62%).
- CH mutations associated with 26% increased lung cancer risk and higher metastasis rates, especially with multiple mutations or VAF ≥ 10%.
- Baseline CH mutations correlated with 18.4% increase in all-cause mortality and 21.3% increase in lung cancer-specific mortality.
- Inflammatory markers partially mediate the relationship between CH and lung cancer incidence.
- Mendelian randomization analysis confirmed a causal role of CHIP in lung cancer incidence.