TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method - PubMed
10 hours ago
- #TGF-β pathway
- #colorectal cancer
- #polygenic risk score
- Study analyzed pooled data of 30,812 colorectal cancer cases and 40,504 controls.
- 204 GWAS variants were annotated; 30 variants overrepresented in four pathways.
- Constructed pathway-based polygenic risk scores (pPRS) from overrepresented pathways.
- Significant interaction found between TGF-β-pPRS and red meat intake on CRC risk.
- Two specific variants in the TGF-β pathway showed interaction with red meat.
- No significant interactions observed with processed meat intake or other pathways.