What's the deal with Alzheimer's disease and amyloid?
9 hours ago
- #Alzheimer's disease
- #research retraction
- #amyloid-beta
- A 2011 Alzheimer's research paper on amyloid-β was retracted from Neurobiology of Aging.
- Multiple studies linking amyloid-β to Alzheimer's have been retracted, with some scientists indicted for fraud.
- Drugs targeting amyloid-β have shown no real clinical effect despite decades of focus.
- Alzheimer's was first identified in 1906, characterized by plaques and tangles in brain tissue, and only diagnosable post-mortem until recent advances.
- Amyloid-β was identified in 1984 as accumulating in plaques, with genetic links to Down syndrome and familial Alzheimer's raising suspicions about its role.