Association of Childhood Acute Leukemia With Autoimmune Diseases - PubMed
2 hours ago
- #epidemiology
- #autoimmune diseases
- #childhood leukemia
- The study explores the link between childhood acute leukemia and autoimmune diseases (AIDs), excluding type 1 diabetes, using Finnish register data from 1990-2019.
- It involved 1,626 leukemia cases and matched controls, finding AIDs associated with an increased risk of leukemia (OR 1.8, 95% CI 1.4-2.4), driven by acute lymphoblastic leukemia (OR 1.9, 95% CI 1.4-2.6).
- Rheumatoid diseases showed the strongest association (OR 2.6, 95% CI 1.3-4.9), and results remained consistent after adjusting for potential biases using lag periods.
- The findings suggest shared immune dysregulation or environmental triggers, warranting further research into the mechanisms connecting leukemia and autoimmune conditions.