Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice - PubMed
5 hours ago
- #microbiome
- #epigenetics
- #immunity
- Weaning transition to solid food diversifies the gut microbiome, triggering a programmed immune response crucial for long-lasting mucosal immunity.
- Gut microbiome changes during weaning shape the DNA methylome and transcriptome of intestinal stem cells (ISCs) in an IFNγ-dependent manner.
- Demethylation of enhancer elements essential for MHC class II genes results in a transcriptional memory that persists into adulthood.
- IFNγ blockade or low-dose penicillin in early life impairs microbiome-mediated epigenetic control and mucosal immunity, exacerbating colitis.
- Murine organoids primed with IFNγ showed rapid, amplified transcriptional responses upon secondary stimulations.
- Early-life events alter the gut microbiome, reprogramming ISC epigenetic memory to shape mucosal immunity.