Hyperthyroidism drives gout risk: A Mendelian randomization observational study - PubMed
19 hours ago
- #Gout
- #Hyperthyroidism
- #Mendelian Randomization
- The study used Mendelian randomization to examine causal relationships between thyroid dysfunction and gout.
- Genetically predicted hyperthyroidism significantly increases gout risk in both UK Biobank and FinnGen cohorts.
- No causal link was found between hypothyroidism and gout.
- Bidirectional analysis ruled out reverse causality, and sensitivity tests supported robust, unbiased results.
- The findings suggest hyperthyroidism is an independent risk factor for gout, warranting uric acid monitoring in affected patients.