Programmable nanomicelles rewire myeloid immunity for durable control of primary and metastatic breast cancer - PubMed
3 hours ago
- #immunotherapy
- #breast cancer
- #nanotechnology
- Programmable nanomicelles target myeloid immunity to control primary and metastatic breast cancer.
- Nanomicelles co-deliver IR825, anti-PD-L1 antibodies, and antagomiR-182 with precision.
- Induces immunogenic cell death, promoting dendritic cell maturation for better antigen presentation.
- miR-182 inhibition repolarizes M2-like macrophages into M1-like phenotypes via TLR4/MYD88/NF-κB pathway.
- Enhances CD8+ T cell infiltration and functionality, leading to durable anti-tumor responses.
- Shows efficacy in suppressing tumor growth, preventing metastasis, and inducing immune memory.
- Validated in patient-derived tumor fragment assays and xenograft models, indicating translational potential.