Parasutterella excrementihominis is associated with attenuated metabolic improvements during obesity therapy in humans - PubMed
3 hours ago
- #obesity
- #diabetes
- #Parasutterella
- Parasutterella excrementihominis is linked to reduced metabolic improvements in obesity therapy.
- Gut microbiome alterations play a role in obesity and type 2 diabetes development.
- Parasutterella species are increased in obesity and type 2 diabetes, affecting triglyceride metabolism and L-cysteine homeostasis.
- A study of 215 subjects showed P. excrementihominis abundance decreases during weight reduction but may rebound during weight maintenance.
- Baseline P. excrementihominis levels inversely correlate with C-reactive-protein improvements.
- Decrease in P. excrementihominis during weight reduction is linked to improved insulin sensitivity.
- Rebound in P. excrementihominis during weight maintenance is associated with weight regain.
- P. excrementihominis may hinder metabolic and inflammatory improvements in obesity therapy.