Implanted flexible electronics reveal principles of human islet cell electrical maturation - PubMed
3 days ago
- #pancreatic islets
- #bioelectronics
- #organoids
- Implanted flexible electronics track human pancreatic α and β cell electrical maturation.
- Longitudinal single-cell tracking links improved hormone responsiveness to increasing activity in SC-α and -β cells.
- Metabolic entrainment reveals circadian hormone secretion rhythms tied to electrical characteristics.
- Electrical stimulation via implanted actuators enhances glucose responsiveness in SC-α and -β cells.
- The study provides a bioelectronic framework to trace and modulate organoid maturation.