Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures - PubMed
4 hours ago
- #neurodegenerative diseases
- #proteomics
- #molecular signatures
- Pan-neurodegeneration proteomics atlas (PanNDA) created from 2,279 human brain samples across 6 major neurodegenerative diseases (NDs).
- Diseases studied include Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal lobar degeneration, progressive supranuclear palsy, vascular dementia, and Parkinson's disease.
- Multi-layer proteomic analysis includes whole proteome, detergent-insoluble proteome, and posttranslational modifications (phosphorylation and ubiquitination).
- Intra-disease analysis reveals molecular subtypes (e.g., three in AD and four in LBD) and dysregulated pathways.
- Inter-disease comparisons identify shared alterations (e.g., GPNMB in microglial activation, NPTX2 in synaptic regulation) and disease-specific changes.
- PanNDA serves as a foundational resource accessible via an interactive website for understanding ND mechanisms.