Efficacy and safety of pharmacological interventions for the maintenance of bipolar disorder: A systematic review and dose-related network meta-analysis across different age groups - PubMed
4 hours ago
- #Bipolar Disorder
- #Network Meta-Analysis
- #Pharmacotherapy
- The study is a systematic review and dose-related network meta-analysis of pharmacological interventions for bipolar disorder maintenance across age groups.
- It analyzed 44 RCTs involving 10,867 participants to compare relapse rates and tolerability.
- Key effective interventions identified include asenapine 20 mg/day, aripiprazole at various doses, quetiapine, lithium, lurasidone, carbamazepine, valproate, olanzapine, and long-acting formulations.
- Sensitivity analysis focused on low-risk-of-bias studies, excluding outliers related to age, gender, BD subtype, baseline severity, and trial duration.
- Findings align with current guidelines and expand knowledge by evaluating drug efficacy and safety across doses and age groups.