Eomes fate-labeling reveals a subset of Eomeslo NK cells that exhibits an ILC1-like phenotype - PubMed
5 hours ago
- #Eomes transcription factor
- #NK cell plasticity
- #Innate lymphoid cells
- Eomes fate-labeling identifies a subset of NK cells with low Eomes expression that show an ILC1-like phenotype.
- This plasticity involves downregulation of Eomes in NK cells and upregulation of ILC1 markers, observed in salivary glands and during Toxoplasma gondii infection.
- Despite adopting ILC1-like traits, these Eomeslo cells differentiate without Hobit, a key ILC1 transcription factor, distinguishing them from true ILC1s.