Peripheral Immune and Metabolic Dysregulation in Migraine, Ménière's Disease, and Vestibular Migraine: A Single-Cell Atlas Study - PubMed
4 hours ago
- #single-cell RNA sequencing
- #immune dysregulation
- #MAPK pathway
- Single-cell RNA sequencing reveals distinct immune cell patterns in migraine (MI), Ménière's disease (MD), and vestibular migraine (VM).
- T cell abundance is significantly increased across these disorders, while monocytes play a key role in metabolic reprogramming.
- The MAPK signaling pathway is identified as a core regulatory pathway upregulated in the diseases.
- PRKCA is highlighted as a core regulator, highly expressed in disease groups and involved in T cell differentiation via the MAPK pathway.
- Herbal and compound screenings identified 1571 interaction pairs, suggesting potential therapeutic targets.