The cGAS-STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology - PubMed
4 hours ago
- #therapeutic target
- #skeletal muscle
- #cGAS-STING pathway
- The cGAS-STING signaling pathway is a key component of the innate immune system and plays a central role in skeletal muscle pathophysiology.
- Aberrant activation of the cGAS-STING pathway due to metabolic stress, injury, aging, toxins, or systemic diseases leads to chronic inflammation, metabolic disturbances, and cell death, contributing to muscle atrophy and fibrosis.
- Moderate activation of the cGAS-STING pathway during physiological adaptation, such as exercise, promotes beneficial metabolic remodeling and muscle fiber transformation.
- Current research challenges include understanding cell specificity, distinguishing between physiological and pathological activation, disease heterogeneity, and improving model systems.
- Potential therapeutic strategies include small-molecule inhibitors, upstream signal intervention, lifestyle management, and targeted biologics, supported by molecular docking analyses.
- Precise modulation of cGAS-STING signaling offers promising translational medicine prospects for treating refractory muscle diseases.