The role of Western diet and gut microbiota in the pathogenesis of cardiovascular diseases - PubMed
3 hours ago
- #Western diet
- #gut microbiota
- #cardiovascular diseases
- The Western diet (WD) is high in fat, sugar, and salt but low in fiber, disrupting gut microbiota homeostasis and contributing to cardiovascular diseases (CVD).
- WD-induced gut dysbiosis leads to the production of harmful metabolites like TMAO and reduces beneficial metabolites such as SCFAs, triggering inflammation, oxidative stress, and metabolic disturbances.
- Interventions like probiotics, prebiotics, the Mediterranean diet, and fecal microbiota transplantation (FMT) can restore gut microbial balance and reduce CVD risk.
- Long-term dietary changes are effective in reshaping the gut ecosystem, highlighting the importance of sustainable lifestyle modifications for CVD prevention.