Pindolol Mitigates Cancer Cachexia by Modulating Inflammation, Lipolysis, and Muscle Atrophy - PubMed
4 hours ago
- #muscle atrophy
- #cancer cachexia
- #pindolol
- Pindolol shows therapeutic potential in mitigating cancer cachexia by modulating inflammation, lipolysis, and muscle atrophy.
- In vitro studies demonstrate pindolol reverses lipolysis induced by B16F10 melanoma cells in 3T3-L1 adipocytes.
- In vivo, pindolol treatment in mice improved body weight, food intake, and reduced systemic inflammation.
- Pindolol preserved skeletal muscle and adipose tissue, improved metabolic parameters like glucose levels and insulin sensitivity.
- Histological analysis confirmed the preservation of muscle and adipose tissue with pindolol treatment.
- Pindolol downregulated genes associated with muscle atrophy (TRIM63, Atrogin-1) and lipolysis (HSL), indicating reduced muscle and fat wasting.