ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration - PubMed
4 hours ago
- #Nanocomposite hydrogel
- #Diabetic tendon regeneration
- #Oxidative stress
- Diabetic patients have higher tendon injury incidence and healing failure risks.
- Tendon stem/progenitor cells (TSPCs) senescence impairs tendon regeneration in diabetes.
- Excessive Ras/MAPK axis activation causes mitochondrial dysfunction and ROS overproduction in diabetic TSPCs.
- A nanocomposite hydrogel (GZPT) loaded with Ganoderma lucidum polysaccharides (GLPs) was developed.
- GZPT suppresses Ca²⁺ influx, inhibiting Ras/MAPK activation and reducing ROS production.
- In vitro, GZPT attenuates dTSPCs senescence and dysfunction.
- In vivo, GZPT promotes structural and functional diabetic tendon regeneration.
- GZPT enables sustained and controlled GLPs release, mitigating oxidative stress niche.