A hierarchical Rorc(γt) cis-regulatory cascade orchestrates differentiation of RORγt⁺ innate immune cells - PubMed
3 hours ago
- #innate immunity
- #RORγt
- #cis-regulatory elements
- Identified two cis-regulatory elements, CNS9 and CNS11, in the Rorc locus that are sequentially used during differentiation of RORγt+ innate immune cells.
- Runx-binding sites in CNS11 establish chromatin accessibility early at the hematopoietic stem cell stage; disrupting this priming prevents RORγt expression.
- CNS9 is critical later, especially for RORγt+ APCs, aiding in colonic peripheral Treg cell induction.
- This hierarchical regulation is vital for secondary lymphoid organ formation, postnatal type 3 immunity, and controlling intestinal type 2 immune responses via pTreg cells.