Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia - PubMed
4 hours ago
- #fibrinogen
- #myelination
- #oligodendrocytes
- Fibrinogen, a blood-derived protein, enters the CNS after blood-brain barrier breakdown and is implicated in multiple sclerosis (MS).
- The study explores fibrinogen's effects on human oligodendrocyte (OL) lineage cells at different developmental stages using iPSC-derived OL precursors and primary OLs.
- Fibrinogen has differential effects based on OL lineage stage: it inhibits maturation and induces an astrocytic phenotype in early lineage OLs but promotes myelination in mature OLs.
- Bone morphogenetic protein (BMP) signaling is activated by fibrinogen in both early and mature OLs and correlates with MS lesion inflammatory activity.
- Findings contrast with rodent studies, showing fibrinogen's lineage-dependent effects, which may inform therapeutic strategies for remyelination failure in MS.