A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation - PubMed
3 hours ago
- #EOMES
- #CD4 T cells
- #intestinal inflammation
- A unique CD4 T cell subset expressing granzyme K (Gzmk) is identified, termed THK cells.
- THK cells are characterized by minimal expression of classical TH-defining factors but high Eomesodermin (Eomes) expression.
- EOMES is necessary and sufficient for THK cell induction and directly drives Gzmk and effector molecule expression.
- THK cell differentiation is independent of TH1, TH2, and TH17 lineages in colitis.
- Genetic ablation of Eomes ameliorates intestinal immunopathology in a T cell-induced colitis model.
- The THK transcriptional program is conserved across species and diverse disease contexts.