Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets - PubMed
7 hours ago
- #lactate
- #lactylation
- #precision oncology
- The Warburg effect describes cancer cells' preference for aerobic glycolysis, leading to lactate production.
- Lactate acidifies the tumor microenvironment (TME) and acts as a signaling molecule and substrate for lysine lactylation (Kla).
- Kla is a novel posttranslational modification (PTM) discovered in 2019, linking glycolytic metabolism to epigenetic and proteomic reprogramming.
- Lactylation modifies histones and nonhistone proteins, influencing oncogenic adaptation and tumor progression.
- Current understanding of lactylation's multifactorial regulation and its therapeutic potential remains incomplete.
- Lactylation plays roles in enhancing DNA repair during chemotherapy, stabilizing signaling effectors in targeted therapy, and promoting an immunosuppressive TME in immunotherapy.
- Regulatory factors of lactylation include competitive PTMs, genetic mutations, microbial influences, and environmental signals.
- Therapeutic strategies targeting lactylation involve indirect modulators and visualization techniques for lactate and lactylation modifications.
- Lactylation represents a reversible metabolic-epigenetic axis for precision oncology, offering potential for predictive biomarkers and novel interventions.