Serological and faecal markers of irritable bowel syndrome: a systematic review and meta-analysis - PubMed
4 days ago
- #IBS biomarkers
- #systematic review
- #meta-analysis
- IBS has biological signatures in immune, microbiome, and enteric nervous systems, but lacks clear biomarkers for diagnosis.
- Systematic review and meta-analysis identified serum and fecal markers distinguishing IBS from healthy controls and organic diseases.
- Top serum discriminators for IBS vs. healthy controls: TNF-α, IL-6, and IFN-γ.
- Fecal calprotectin was higher in IBS patients compared to controls, but lower than in organic diseases.
- Serum albumin and fecal calprotectin effectively differentiated IBS from organic diseases.
- IBS-D subtype distinguished by lower serum albumin and higher IL-6 levels compared to controls.
- Increased peripheral cytokine levels in IBS suggest epithelial permeability and potential for subgroup differentiation.
- Study highlights biological signatures in IBS that could aid clinical diagnosis and understanding disease mechanisms.