New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma - PubMed
5 hours ago
- #proteomics
- #fetal death
- #biomarker
- Study identified new maternal plasma protein biomarkers to improve prediction of fetal death beyond known markers PlGF and sFlt-1.
- Analysis of over 7,000 proteins found 87 unique proteins significantly dysregulated in fetal death cases, mostly involved in pregnancy processes like angiogenesis.
- Random forest models combining new proteins with PlGF/sFlt-1 increased AUC from 72% to 86%, boosting sensitivity from 53% to 74% at similar false-positive rates.
- Top candidate biomarkers enhancing discrimination include CGA, DNAJB9, and POLR3K, with some proteins showing unique dysregulation in fetal death compared to preeclampsia.
- Proteomic changes in fetal death are correlated with late preeclampsia but represent a more severe state with distinct perturbed pathways, suggesting both shared and separate mechanisms.