Unmasking Hormonal Mechanisms of Hypertension in Obesity - PubMed
4 hours ago
- #hormonal-mechanisms
- #hypertension
- #obesity
- Study focuses on hormonal mechanisms in obesity-related hypertension to inform targeted therapy.
- Participants with obesity and hypertension were analyzed for aldosteronism and hypercortisolism phenotypes.
- 51.9% had primary aldosteronism, with half showing superimposed renin-dependent aldosteronism.
- 23.4% exhibited only renin-dependent aldosteronism, characterized by higher aldosterone and kaliuresis.
- 9.2% had hypercortisolism, indicating overlapping pathological phenotypes in over 80% of cases.
- Findings support aldosterone- and cortisol-directed therapy for obesity-related hypertension.
- Research funded by NIH and other grants, with disclosures of consulting fees and patents by some authors.