ZBP1 as a dynamic monitor of viral replication: implications for therapeutic strategies - PubMed

4 hours ago

ZBP1 is an innate immune sensor that recognizes Z-NAs, a nucleic acid structure formed during viral replication.
ZBP1 acts as a dynamic monitor of viral replication, not just a static alarm, with its function influenced by subcellular localization.
ZBP1 serves as a molecular scaffold, where ligand-induced amyloid assembly concentrates kinases to initiate cell death.
ZBP1 employs a dual antiviral strategy involving NF-κB-mediated inflammation and PANoptotic cell death.
Viruses have evolved countermeasures like 'signal masking' (poxvirus E3) and 'signal interception' (herpesvirus ICP6) against ZBP1.
ZBP1 plays a dual immunomodulatory role, contributing to both antiviral defense and immunopathology.
The review suggests a replication-centric perspective for developing stage-based therapies targeting the ZBP1 pathway.

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