Effects of a 24-week resistance exercise program on brain amyloid and Alzheimer's disease blood-based biomarkers: the AGUEDA randomized controlled trial - PubMed
4 hours ago
- #Biomarkers
- #Alzheimer's Disease
- #Resistance Training
- A 24-week resistance training program was tested on 90 cognitively normal, inactive older adults aged 65-80.
- The study aimed to assess changes in brain amyloid-β (Aβ) and Alzheimer's Disease (AD)-related blood biomarkers.
- No significant differences were found in brain Aβ or AD-related biomarkers between the exercise and control groups.
- The ptau217/Aβ1-42 IPMS ratio showed a small, non-significant increase in the control group but remained stable in the exercise group.
- Subgroup analyses indicated differential responses based on amyloid PET-positivity and APOE4 status.
- APOE4 carriers and amyloid PET-positive individuals in the control group showed increased Aβ levels, while the exercise group showed reductions.
- Resistance exercise may modulate AD pathophysiology, particularly in vulnerable populations.