Noninvasive tactile stimulation engaging a thalamic-amygdala circuit ameliorates mood dysfunction in mouse models of depression-like behavior - PubMed
5 hours ago
- #thalamic-amygdala circuit
- #E/I balance
- #tactile stimulation
- Noninvasive tactile stimulation (tactile experience enrichment, TEE) improves mood-related behaviors in mouse models of post-stroke depression and chronic stress.
- TEE engages a specific thalamic-amygdala circuit from the reuniens nucleus (Re) to BLA inhibitory neurons, restoring excitatory/inhibitory (E/I) balance in the basolateral amygdala.
- This ReExc-BLAInh pathway compensates for impairment in the medial prefrontal cortex-BLA circuit, reducing depressive- and anxiety-like symptoms.
- Both chemogenetic activation of the ReExc-BLAInh pathway and TEE produce similar therapeutic effects, highlighting its potential as a circuit-based therapy.