Distribution of Lantibiotic Susceptibility and Its Association With Two-Component Regulatory Systems in Staphylococcus aureus Clinical Isolates - PubMed
3 hours ago
- #lantibiotics
- #bacteriocin resistance
- #Staphylococcus aureus
- The study examined susceptibility to four lantibiotics (nisin A, Pep5, nukacin ISK-1, epidermin) in 149 clinical Staphylococcus aureus isolates.
- Some strains showed higher susceptibility to epidermin, nukacin ISK-1, and nisin A, associated with impaired function of the two-component regulatory system (TCS) BraRS.
- Mutations (frameshifts or nonsense) in braR, braA, braB, or absence of vraDEH genes were found in susceptible strains.
- Frameshifts in the GraR TCS and VraG transporter genes also increased susceptibility to nisin A, Pep5, and nukacin ISK-1.
- Susceptibility varied by clonal complexes (CCs): CC45 was more susceptible to nisin A, Pep5, and nukacin ISK-1, while CC5 was less susceptible.
- Cell surface net negative charge did not differ significantly among CCs, suggesting factors beyond BraRS and GraRS influence susceptibility.
- These insights aid in evaluating bacteriocins as potential novel antimicrobial agents against S. aureus.