Outcomes and Safety of Revascularization Approaches for Stroke Related to Isolated Vertebral Artery Occlusions (BRAVO) - PubMed
3 days ago
- #revascularization
- #ischemic stroke
- #vertebral artery occlusion
- The study investigates revascularization strategies for acute ischemic stroke caused by isolated vertebral artery occlusion.
- A retrospective, international, multicenter cohort study included 494 patients from 30 comprehensive stroke centers across Europe, North America, and Asia between 2016 and 2022.
- Patients were divided into three treatment groups: conservative treatment (Cx), intravenous thrombolysis (IVT)-only, and endovascular treatment (EVT)±IVT.
- IVT-only showed similar 3-month modified Rankin Scale (mRS) scores compared to Cx but had greater early neurological improvement and higher recanalization rates.
- EVT±IVT was associated with unfavorable mRS shift scores, higher early neurological deterioration of ischemic origin, and symptomatic intracerebral hemorrhage, despite higher recanalization rates.
- Patients with National Institutes of Health Stroke Scale (NIHSS) score ≥10 showed potential benefits from EVT+IVT.
- The study concludes that IVT-only appears safe and effective, while EVT±IVT may be beneficial for moderate-to-severe strokes, warranting further prospective trials.