Self-polymerized polyphenol-based platform for the management of dry eye pathogenesis - PubMed
5 hours ago
- #nanoparticles
- #polyphenol
- #dry eye disease
- Development of a polyphenol-based eye drop for dry eye disease (DED) management.
- Utilizes self-polymerization of rosmarinic acid with hyaluronic acid and cerium ions to form RHC NPs.
- Enhanced ocular retention with thiol-decorated s-RHC NPs.
- Demonstrated comprehensive symptom relief in DED mouse models, including inflammation suppression and tear secretion recovery.
- Potential to inspire future polyphenol-based nanoparticle designs via self-polymerization.