Cell-type-focused compound screen in human organoids reveals CK1 inhibition protects cone photoreceptors from death - PubMed
4 hours ago
- #human retinal organoids
- #CK1 inhibition
- #cone photoreceptors
- A large-scale compound screen was conducted using 20,000 human retinal organoids with GFP-labeled cone photoreceptors.
- CK1 inhibitors were identified as protective for cone photoreceptors against degeneration.
- HSP90 inhibitors showed short-term protection but long-term damage to cones.
- Broad HDAC inhibition by various compounds significantly damaged cones.
- The protective effects of CK1 inhibitors were confirmed in a mouse model of photoreceptor degeneration.
- The study provides a database of cone-damaging compounds and potential targets for neuroprotection in diseases like macular degeneration.