The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity - PubMed
3 hours ago
- #neurodevelopment
- #autism
- #ubiquitin ligase
- UBE3B is an E3 ubiquitin ligase involved in neurodevelopmental processes.
- Mutations in UBE3B are linked to autism spectrum disorder (ASD) and intellectual disabilities.
- A Ube3b knockout mouse model showed deficits in vocalization, social behavior, learning, memory, and motor skills.
- UBE3B loss leads to defects in dendritic morphogenesis and reduced excitatory synapse density.
- Proteomic analysis identified 116 proteins with altered levels and ubiquitination in UBE3B-deficient neural stem cells.
- UBE3B interacts with key synaptic proteins like ATP1A1, DOCK7, NLGN2, and STX12.
- The study suggests UBE3B's role in fine-tuning the synaptic proteome is critical for normal brain function.