Integrative profiling of lactylation reveals prognostic biomarkers and an immunosuppressive niche in acute myeloid leukemia - PubMed
4 hours ago
- #immunosuppressive niche
- #lactylation
- #AML prognosis
- The study profiles lactylation in acute myeloid leukemia (AML), linking metabolic reprogramming like the Warburg effect to prognosis and the tumor microenvironment.
- Seven lactylation-related genes (LRGs) were identified as hub genes: LSP1, MPO, GZMB, SPINK2, HLA-DRB1, HLA-DRA, and POU2F2, with GZMB and LSP1 validated via Mendelian randomization.
- Key LRGs are enriched in immune and inflammatory pathways, and a generalized linear model (GLM) performed best as a prognostic model validated on external datasets.
- Experiments showed increased lactylation in AML cell lines with exogenous lactate boosting lactylation and upregulating GZMB and LSP1, while sodium oxamate reduced lactylation.
- Molecular docking identified potential drugs targeting GZMB and LSP1, offering insights for therapeutic strategies in AML.