Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease: Protection Through PTEN Inhibition - PubMed
5 hours ago
- #heart failure
- #PTEN inhibition
- #phosphoinositide signaling
- Chronic AngII exposure disrupts cardiac phosphoinositide (PI) homeostasis, leading to impaired cardiac function.
- AngII infusion reduces PI, phosphatidylinositol (4,5)-bisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate levels.
- CaV1.2 channels redistribute from t-tubules to endosomal compartments, but Ca2+ currents are maintained via PKA and CaMKII phosphorylation.
- PTEN inhibition preserves Akt signaling, protecting against cardiac dysfunction and fibrosis without reversing cellular remodeling.
- PTEN inhibition emerges as a potential therapeutic strategy for heart failure linked to renin-angiotensin system activation.