Tumour promotion through the lens of evolution - PubMed

3 hours ago

Normal human tissues contain many cells with cancer driver mutations but still maintain homeostasis, indicating that mutations alone are insufficient for tumor formation.
Many known carcinogens are not mutagens, suggesting that exogenous exposures may promote cancer by altering selective pressures rather than directly causing mutations.
Tumor promotion involves Darwinian evolutionary processes, where clonal selection of pre-existing mutated cells is influenced by environmental or endogenous factors.
Understanding tumor promotion through evolutionary principles can inform cancer prevention strategies by targeting factors that promote clonal expansion.

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