Vitreoretinal Surgery for Intraocular Complications Following Radiotherapy Treatment of Uveal Melanoma - PubMed

5 hours ago

Globe-sparing radiotherapy is widely used for uveal melanoma but often leads to complications requiring vitreoretinal surgery.
A study reviewed 1794 patients treated with radiotherapy for uveal melanoma (2012-2022), with 70 undergoing secondary vitrectomy.
Complications requiring vitrectomy were more common after proton-beam radiotherapy (5.4%) than plaque brachytherapy (3.0%).
Common indications for vitrectomy included vitreous haemorrhage (39%) and retinal detachment/toxic tumour syndrome (31%).
Tumors requiring vitrectomy were larger, often ciliary body in origin, and associated with worse prognosis.
Vitrectomy patients had higher rates of enucleation (9% vs. 3%), metastasis (16% vs. 6%), and visual decline (average 0.60 LogMAR).
Limited visual improvement was observed (≥3-line gain in 13%), with proton-beam patients having worse outcomes than plaque brachytherapy.
Timely vitreoretinal intervention by experienced specialists can help patients retain their eyes, avoiding enucleation.
Multidisciplinary collaboration between vitreoretinal surgeons and ocular oncologists is crucial for managing complications and improving outcomes.

Hasty Briefsbeta