Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types - PubMed
3 hours ago
- #single-cell atlas
- #fetal growth restriction
- #pregnancy
- A transcriptomic atlas of 2.56 million single cells from 115 fetal pig tissues and 119 tissues from its pregnant mother was created.
- Heart capillary endothelial cells with enhanced fatty acid transit capability were found enriched during pregnancy but restored post-gestation.
- L-leucine transport insufficiency in trophoblasts was identified as a cause of fetal growth restriction, affecting muscle type II myofiber subclusters.
- The 'all-from-one' strategy helped identify tissue cell type-specific transcription factors and provided insights into pregnancy heart adaptation and fetal growth restriction.