Targeting DDR1 with novel synthesized antagonists delays cellular aging and enhances wound healing in mesenchymal stem cells - PubMed
4 days ago
- #Mesenchymal Stem Cells
- #Regenerative Medicine
- #DDR1
- Novel phthalimide-based inhibitors (AC-4067 and AC-4061) target DDR1 with high potency and selectivity.
- AC-4067 enhances proliferative capacity and wound healing in Wharton's jelly-derived MSCs without affecting pluripotency markers.
- DDR1 inhibition reduces replicative senescence markers (p16, p21, p53) and DNA damage signaling (γH2AX).
- The findings suggest DDR1 as a key regulator of MSC aging and genomic stability.
- AC-4067 shows potential as a pharmacological agent to improve MSC therapeutic applications in regenerative medicine.