B cell receptor signaling in autoimmune rheumatic diseases: regulatory mechanisms and therapeutic targeting - PubMed
4 hours ago
- #B cell receptor signaling
- #autoimmune rheumatic diseases
- #precision medicine
- Autoimmune rheumatic diseases (ARDs) are chronic disorders with immune dysregulation and multi-organ inflammation.
- B cell receptor (BCR) signaling is a key pathogenic mechanism in ARDs, driving B cell activation and autoantibody production.
- BCR signaling varies across ARDs, influencing disease-specific mechanisms and therapeutic responses.
- The review covers BCR signaling's role in rheumatoid arthritis, lupus, Sjögren's syndrome, IgG4-related disease, and ANCA-associated vasculitis.
- Clinical trial data on BCR-targeted therapies are discussed, including variability in treatment responses.
- Future directions include precision medicine, biomarker-guided strategies, and combination therapies to improve outcomes.