The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer - PubMed
19 hours ago
- #Pancreatic Cancer
- #HIF-2 Transcription Factor
- #Ferroptosis Resistance
- HIF-2 transcription factor confers ferroptosis resistance in pancreatic cancer under hypoxia and tumor fluid conditions.
- It enhances cysteine uptake via system Xc- and transsulfuration enzymes (CBS, CTH) to boost glutathione production, countering lipid peroxidation.
- HIF-2 also promotes mitophagy via Parkin, reducing mitochondrial ROS and suppressing ferroptosis-inducing factors.
- This mechanism explains why KRAS-mutant pancreatic tumors show relative ferroptosis resistance despite common mutations.