The gut microbiome in graft-versus-host disease: mechanisms of immune modulation and therapeutic approaches - PubMed
4 days ago
- #immune modulation
- #GvHD
- #gut microbiome
- Graft-versus-host disease (GvHD) is a major complication of allogeneic hematopoietic stem cell transplantation.
- The gastrointestinal (GI) tract plays a key role in GvHD morbidity and mortality, and it also contains a complex and abundant microbial reservoir.
- The gut microbiota influences GvHD through both innate and adaptive immunity, potentially activating donor T-cells via microbial antigens.
- Therapeutic approaches to modify the gut microbiota for GvHD treatment include broad decontamination, pre/probiotics, and fecal microbiota transplantation.
- Over 40 clinical studies in the last 40 years have explored microbiota-targeted therapies for GvHD.