Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells - PubMed
5 hours ago
- #nanomedicine
- #senotherapy
- #retinal aging
- Senescent cells contribute to retinal aging and disease progression.
- Bst2 identified as a selective marker for senescent retinal pigment epithelium (RPE) cells.
- Developed B-Z-PON, a targeted drug delivery platform using anti-Bst2 antibodies.
- B-Z-PON selectively delivers drugs to senescent RPE cells, sparing healthy cells.
- ABT-263-loaded B-Z-PON improved visual function in aged and degeneration models.
- Findings offer a promising approach for treating age-related macular degeneration.