Neuroprotective Effects of Strength Training on Behavioral Deficit, Oxidative Damage, Astrogliosis, and Neuronal Death in a Bipolar Disorder Model - PubMed
4 days ago
- #bipolar disorder
- #neuroprotection
- #strength training
- Strength training shows neuroprotective effects in a bipolar disorder (BD) model.
- An 8-week strength training protocol in rats prevented behavioral disturbances like manic- and depressive-like behaviors and cognitive impairments.
- Training attenuated oxidative stress, neuroinflammation, and neuronal cell death in the cerebral cortex and hippocampus.
- Exercise normalized antioxidant enzyme activities and reduced reactive species accumulation.
- Strength training prevented NF-κB activation and decreased markers of astrogliosis (GFAP) and neurodegeneration (Fluoro Jade-C).
- Findings suggest strength training modulates redox homeostasis, inflammatory signaling, and neuronal integrity in BD.