Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades - PubMed
4 hours ago
- #B-vitamins
- #meta-analysis
- #cardiovascular diseases
- B-vitamin combinations' effects on cardiovascular diseases were analyzed through a systematic review and meta-analysis of RCTs over three decades.
- The study found nonsignificant reductions in stroke and major adverse cardiovascular events (MACE) with B-vitamin combinations.
- No significant effects were observed for all-cause mortality, cardiovascular mortality, or myocardial infarction (MI).
- In primary prevention populations, significant reductions in stroke and MACE were noted.
- A modest reduction in MACE was also observed in secondary prevention populations.
- The study highlights heterogeneity in trial populations, vitamin formulations, and outcome definitions as limitations.
- B-vitamin combinations may reduce stroke and MACE in selected primary prevention populations, suggesting baseline cardiovascular risk and folic acid fortification influence treatment effects.