Vitamin B12 Attenuates Post-Ischemic Brain Fibrotic Remodeling and Suppresses MAPK1 Signaling in Male Rats - PubMed
3 hours ago
- #Neuroprotection
- #Stroke Therapy
- #Fibrosis
- Vitamin B12 improves outcomes in ischemic stroke by reducing fibrotic remodeling via suppression of MAPK1 signaling.
- Integrated network pharmacology and Mendelian randomization identified ALDH2 and CD40 as protective factors and MAPK1 as a risk driver.
- In vivo studies in male rats show vitamin B12 lowers MAPK1 expression and key fibrosis markers, enhancing motor recovery.
- Vitamin B12 may modulate a 'metabolism-immune-matrix' network, positioning MAPK1 as a target for long-term stroke therapy.