Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea - PubMed
3 days ago
- #rosacea
- #fibrosis
- #macrophage
- Rosacea is a chronic inflammatory skin disorder with limited treatment options.
- Macrophage-to-myofibroblast transition (MMT) contributes to fibrotic remodeling in rosacea.
- TGF-β1 is prominently elevated in rosacea patients.
- Single-cell RNA sequencing and spatial transcriptomics show fibrotic remodeling even in inflammation-dominant stages.
- Macrophage depletion alleviates fibrotic remodeling, highlighting MMT's pathogenic role.
- Bruceine A (BA) suppresses fibrotic remodeling by reducing MMT and attenuating inflammation.
- BA targets STAT3, disrupting its palmitoylation-dependent activation and profibrotic signaling.
- MMT is identified as a driver of fibrotic remodeling in rosacea.
- STAT3 palmitoylation is a potential therapeutic target.
- BA is a dual-acting candidate for rosacea treatment.