Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model - PubMed
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- #malaria
- #phagocytosis
- #immune response
- Comprehensive immune profiling in a rodent malaria model reveals IFN-γ signaling in T cells mediates parasite phagocytosis.
- Disruption of IFN-γ signaling in T cells reduces parasite load and lung pathology by enhancing T cell-monocyte interaction.
- A proinflammatory monocyte subset (CD8+Ly6C+) shows elevated phagocytic capacity, contributing to malaria-associated lung pathology.
- The study highlights the complex immune network induced by Plasmodium infection, emphasizing the role of IFN-γ signaling in T cell-monocyte interactions.