The International Association for the Study of Lung Cancer Pleural Mesothelioma Staging Project: Impact of Common Molecular Alterations and PD-L1 Expression on Overall Survival in a Select Cohort from
3 hours ago
- #Biomarkers
- #Molecular alterations
- #Pleural mesothelioma
- The study examines the impact of common molecular alterations and PD-L1 expression on overall survival (OS) in pleural mesothelioma (PM).
- Pathogenic alterations in BAP1 were most common (55.0%), followed by CDKN2A (36.2%), NF2 (23.8%), and TP53 (18.1%).
- Loss of BAP1 expression by IHC was detected in 57.5% of cases, and PD-L1 expression was positive in 44.5% of cases.
- Univariate analysis showed CDKN2A, NF2, and TP53 alterations were associated with worse OS, while BAP1 alterations and loss of expression were linked to better OS.
- Multivariable analyses confirmed these associations, with BAP1 alterations plus CDKN2A, NF2, and TP53 alterations along with clinical covariates best predicting survival.
- The study concludes that genomic alterations provide additional prognostic information beyond anatomic TNM and clinicopathologic features in PM.